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Acute Toxicity Study of Mangiferin

Author(s): P.K.Babu, K.Bhuvaneswari and C.Azhaguraman

ABSTRACT

The aim of this work was to find the toxicity of isolated mangiferin from leaves of Mangifera indica L. var Alphonso by Brine shrimp lethality assay (BSLA) and Mutagenesis assay on Drosophila melanogaster. In brine shrimp lethality assay (BSLA), which based on the ability to kill laboratory cultured brine shrimp (Artemia nauplii), brine shrimp was treated with mangiferin of different concentration (5-40ppm). In mutagenesis method larvae was treated with mangiferin of various concentration (10, 25, 50 & 100mM) along with negative control (distilled water) and standard chemical mutagen (0.5% V/V formalin).In BSLA LC50 for mangiferin was 10ppm in 24hrs. It showed that mangiferin was safe and consistent with the reported data. In mutagenesis assay results of mangiferin at all concentration showed no significant morphological changes in the D. melanogaster on comparing formaldehyde exposed flies. Hence results revealed that mangiferin was not acutely toxic.

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