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ANTI TUMOUR ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF BOERHAAVIA DIFFUSA LINN AGAINST DALTON ASCITIC LYMPHOMA& EHRLICH ASCITIC CARCINOMA IN MICE

Author(s): G.Nalini, Ajithadas aruna and N.Chidambaranathan

ABSTRACT

The present study aims to evaluate the antitumor activity of hydro alcoholic extract of whole plant of Boerhaavia diffusa linn on Dalton Ascitic Lymphoma (DAL) and Ehrlich Ascitic carcinoma (EAC) in Swiss Albino mice model.The tumor was induced in mice by intraperitoneal injection of DAL (1X106cells/mouse). Hydro alcoholic extract of Boerhaavia diffusa linn (HAEBD) was administered to the experimental animals at a dose of 200mg/kg & 400mg/kg after 24 h of DLA induced tumor inoculation. The activity was assessed by increase in life span, average decrease in body weight, tumor weight, tumor volume, viable cell count, packed cell volume, hematological and biochemical parameters.The potency of the extract was compared with standard 5-flurouracil (20mg/kg I.P).HAEBD treatment showed significant increase in the life span, decrease the cancer cell count and tumor weight in the DLA tumor induced mice. The results showed decrease in tumor volume and cell viability. The antitumor effect of HAEBD was also evaluated by assessing hematological parameters and biochemical parameters.  Hematological parameters like red blood cell count, hemoglobin content and platelets cell values were restored to near normal level by HAEBD in tumor induced mice. In addition, HAEBD brought back the altered levels of liver enzyme towards normal value. Histopathological studies also reveals the normal architecture of liver tissues.In conclusion, the present study results revealed that Hydro alcoholic extract of Boerhaavia diffusa linn possessed significant antitumor activity against DAL and EAC models in mice.

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