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DEVELOPMENT & CHARACTERIZATION OF KETOPROFEN EMULGEL FOR TOPICAL DELIVERY

Author(s): Hiba Harshan and Krishnapillai M

ABSTRACT

The major objective behind this formulation is to enhance the topical delivery of hydrophobic drug (ketoprofen) by formulating ketoprofen Emulgel using high molecular weight water soluble polymer of Hydroxypropyl methylcellulose (HPMC), Carbopol 940, CMC. with an objective to increase transparency and spreadability. The prepared emulgel were evaluated for their physical appearance, pH determination, viscosity, spreadability, extrudability, in vitro drug release, Stability and pharmacokinetic studies. All the prepared emulgel showed acceptable physical properties, homogeneity, consistency, spreadability, viscosity and pH value. The formulation noted as F1 showed comparable percentage of drug release when they compared with standard diclofenac sodium emulgel. In addition to this, The in vitro release rate of emulgel was evaluated using Diffusion cell containing dialysis membrane with phosphate buffer pH 7.4 as the receptor medium. The results of the present study show that, the Emulgel was found to be stable with respect to physical appearance, pH, Rheological properties and drug content even at all temperature and conditions for three month and it is better suitable for topical delivery routes.

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