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DYSLIPIDEMIC AND HAEMATOLOGICAL EFFECTS OF CRUDE AND FRACTIONS OF HENSIA CRINITA IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Author(s): Iwara A. Iwara, Godwin O. Igile, Godwin E. Okon  and Patrick E. Ebong

ABSTRACT

This study was carried out to evaluate the hypolipidaemic and haematological effects of extracts of Hensia crinita (H.C) in STZ-induced diabetic rats. Thirty Wistar rats weighing 120-150g rats were divided into six groups of 6 rats each. Diabetes was induced using 45mg/kg b.w of STZ in 0.1M sodium citrate buffer. Control groups were treated with 20% dimethylsulfoxide and test groups treated with glibenclamide (5mg/kg bw), 400mg/kg b.w crude H.C, 100% and 30% methanol fractions of H.C respectively. The results showed  significant decrease (p<0.05) in concentrations of all lipid except for HDL-C concentration which showed no significant (P>0.05) change in diabetic rats treated with crude, 100% and 30% methanol fractions of H.C compared to the diabetic control group. Significant (p<0.05) changes were observed for haematological indices of all treated groups compared to diabetic and normal control groups except for RBC and Hb which showed no significant change (P>0.05) in all extract treated groups. The results thus suggest that administration of crude and extract fraction of H.C may contribute significantly to reduction of lipid parameters in diabetes and also could curtail haematological insults posed by diabetes and thus, useful in the management of diabetes.

Keywords: Heinsia crinita; Streptozotocin; Lipid profile; Haematological indices.

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