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EVALUATION OF ANTI-ULCER ACTIVITY OF CINNAMOMUM TAMALA LEAVES EXTRACT ON EXPERIMENTAL ANIMALS

Author(s): C.Manikandhan, Jayaraman Rajangam

ABSTRACT

The present study was designed to study the antiulcer potential of 50% ethanolic extract of Cinnamomum tamala (EECT) on experimentally induced ulcer models like pylorus ligation, ethanol, and aspirin.In all three models, the effect of ethanol extract of Cinnamomum tamala was observed by calculating ulcer index based on lesion index and pH. The results of te present investigation reveal that in all three models studied, EECT (50,100 and 200 mg/kg,p.o) produced a dose-dependent significant protection against ulcer models in animals. But among the dose levels EECT at 200 mg/kg dose significantly (p<0.05) changed the gastric volume, ulcer index, and pH. In conclusion, the results indicated that ethanolic extract of Cinnamomum tamala shows significant antiulcer activity by inhibiting the gastric lesions and provides the significant gastroprotective effect which may be associated with its antioxidant property.

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