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HYPERGLYCEMIA: A RISK FACTOR FOR TUBERCULOSIS

Author(s): Harish Kumar,  Poonam Thakur, Monika Chauhan and Vivek Sharma

ABSTRACT

Tuberculosis (TB) is a chronic and serious infection which affects endocrine function of pancreas, adrenal, thyroid and pituitary, warranting exogenous insulin and other hormone replacements. TB can be asymptomatic or latent for whole life unless a concurrent pathologic condition like hyperglycemia is not present. TB is thought to exacerbate and worsen the outcome for diabetes mellitus (DM) and vice versa is also true. TB is so aptly described as a complication of DM as people with diabetes are more susceptible to infections due to their immuno-compromised status with reactivation of older foci of TB rather than through fresh contact. They often exhibit lower lobe involvement more commonly than in non-diabetics. Various studies have shown that 5-30% of patients with TB have DM as well. T cells, Interferon’s, interleukins are various mediators and autophagy, chemotaxis and antigen presentation are the various complicated pathways that precisely interlinks diabetes and tuberculosis. The present work advocates screening for diabetes while individualizing drug therapy in patient with tuberculosis.

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