Author(s): A.Sumathy, S.Palanisamy, K.N.Arathi, D.Karthik and M. Srinivasan
Thiazoles and their derivatives have long been used as precursors for the synthesis of biologically active molecules because of the wide spectrum of activity shown by the thiazole moiety. Numerous thiazole compounds substituted with a different group of various positions have been prepared, despite this importance of 2-aminothiazoles have not been previously reviewed. In recent years, several new methods for the preparation of 2-aminothiazole derivatives and reactions have been reported, including waste free techniques. Various substituted phenyl thiazoles were synthesized by the reaction of substituted acetophenone and thiourea in the presence of iodine, where cyclization takes place and these thiazoles were further treated with isatin, those gave respective Schiff bases. The newly synthesized compounds were characterized by IR spectral studies and screened for antitubercular activity against Mycobacterium tuberculosis whereas antimicrobial activity was performed against B.subtilis, E.coli, and C.albicans. The findings of the present investigation highlights, the synthesized thiazoles possessing good anti-tubercular, anti-microbial activities due to the incorporation of secondary amines with the substituted thiazoles.