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A PROSPECTIVE OBSERVATIONAL STUDY TO ASSESS THE INDICATIONS AND THE ADVERSE EVENTS OF PROTON PUMP INHIBITORS AMONG PATIENTS VISITING A TERTIARY CARE HOSPITAL IN COIMBATORE, INDIA

Author(s): Prestin Thomas, Arulraj Ramakrishnan, A.Vijayakumar, G.Sathyapraba  and K.T.Manisenthilkumar

ABSTRACT

The incidence of inappropriate use of proton pump inhibitors (PPIs) varies from 40-60% in various studies. The present study was planned with the aim of finding out the rational use of proton pump inhibitors (PPIs) in the patients of a tertiary care hospital. Prospective observational study of PPIs was conducted in Kovai Medical Center and Hospital for 5 months in the inpatients of Gastroenterology, General medicine and Neurology. The sample size of the study was 200. Rationality was determined by comparison with National Institute of Clinical Excellence (NICE) Guidance.Data of 200 inpatients were collected during the study period, in which 71.5% were males and 28.5% were females. It was observed that, of the Proton Pump Inhibitors used, Pantoprazole was utilized the most, constituting 66.5% of total prescriptions. When compared to the NICE guidelines, the study reveals that only 53% of the PPI’s were prescribed for approved indications for GI disorders followed by 23% for prophylaxis of the same. For 24% (n=48) of patients, there was no documentation of valid indication for being on PPI. Since there is an increase in number of GI disturbances and hence the uses of PPI’s, more studies are needed to ensure its use in those indications and to have a rational prescription of PPI. For a developing country like India, where the use of PPIs is increasing, it is high time to formulate a National Drug policy to rationalize drug use.

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