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STUDY OF ANTIOXIDANT ACTIVITY OF MONOOLEIN BASED LIQUID CRYSTALLINE NANOPARTICLE OF QUERCETIN

Author(s): Pooja Poulose and Roma Mathew

ABSTRACT

The objective of the study was to entrap Quercetin into the monoolein and to conduct antioxidant studies.Liquid-crystalline state is an intermediate between an ordered crystal and a disordered isotropic liquid. It has properties related to both liquids and crystals.Monoolein, is a polar unsaturated monoglyceride, they form thermodynamically stable self- assembled structures like liquid crystalline nanoparticles by ultrasonication in presence of aqeous phase. 2,2 Diphenyl-1-picryl hydrazyl (DPPH) and nitrogen oxide free radical scavenging activity was studied. IC50value of nanoparticles was found to be 0.1188µg/ml and that of standard was 0.7001 µg/ml in DPPH assay. Inhibitory concentration 50 (IC50) value of nanoparticle was found to be 7.86 µg/ml and that of standard was 13.68 µg/ml. Quercetin entrapped nanoparticle has a promising effect as an antioxidant.

Keywords: Quercetin, Monoolein, Liquid crystalline nanoparticles (LCN), Antioxidant.

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